I'm still working that out, to be honest. And again, I'm not so sure it is different per se.
There seems to be these issues of scale, wickedness (or as Philip Hunter put it, layers of relationships and networks) that seem to manage up. There is more of a need to address systems level thinking, instead of man:machine level thinking. I find that Enterprises are de facto services in their nature.
Some people think that Enterprise just means doing the Non-design stuff differently, but that is the same for all parts of the organization.
I'm finding that to be definitely true as well. But I want to do it in a designerly way. So how? Applying VizThink to change management, change initiation, change success? Prototyping possible futures of the organization, not just of the touchpoints. And of course, you can do the same thing w/ many many consumer related things as well.
I think we actually are missing the tools for really dealing w/ the level of wickedness in deep enterprise solutions, infrastructural elements, etc. Where not just the customer and user are separated but where the user is not even the problem owner.
Here's what I do know. I go to events that don't make this distinction and the topics fall flat. They don't address my personal context and I hear many other people saying the same thing. It also feels like common sense to me.
Why would I ever design software for an ERP system, oil rig, etc., the same way that I design a social network, a travel site, a newspaper, etc?
Maybe I should be, but my mind tells me that is a fools errand. But I've been doing Enterprise for so long, maybe I am doing it the same way as Consumer is done. Doesn't seem that way when I listen to people working in the consumer space.